Clenbuterol

Clenbuterol
(Člen) Clenbuterol (clen) is a selective beta-2 agonist / antagonist and a bronchodilator. What does this mean that it stimulates the beta-2 receptors. Of great importance is the fact that clenbuterol is a selective beta-2 agonist (because it works selectively on beta-2-andrenergic receptors), right? In fact, clenbuterol selective ... as typing a line (the line in your beta-2), with a small hammer (a hammer is the Člen) ... Thus, it enters the beta-2 receptors selectively. Sorry if this is repetitive, but it is very important to understand that before we move. Since clenbuterol has very little beta-1 stimulating ability, it has the potential to reduce certain types of air without the cardiovascular effects (more about that later), and for this reason it is used as medication against asthma. So what is the dose of stimulant as Člen (or ephedrine), where it stimulates the beta receptors? Well, it serves to increase the body temperature of a little heat due to increased production in the mitochondria, increase your base metabolic rate and decreased appetite (1). This partly explains how Beta-2 agonists directly stimulate fat cells and increase lypolysis (FAT-loss) (1) (13). And also because it is a beta-2 agent, clen can decrease insulin sensitivity (2), unfortunately. Clenbuterol fat loss Clenbuterol is a very effective pre-and this is what he is most often used in sporting circles. This will increase your rate of fat-free mass (mission) for the fat by reducing your fat and increase the mission of May (3). You can quantify it as follows: In one study, horses Given half a reasonable dose of clen (slightly over 1mcg/lb X2 per day) and is carried out on 20 minutes, 3 times a week (I think they Mentzer disciples) had significant reduction in% fat (-17.6%) and fat mass (-19.5%) for 2 weeks, which is similar to Člen given to horses who do not exercise, however, the group has carried out various missions response that increased significantly (+4.4%) at week 6 (3). Week 6! Here is a diagram illustrating changes in% fat of experience in the different test groups, followed by a chart showing the increase in fat free mass seen the same group: Changes in the percentage of body fat (% fat) over time and the period in clenbuterol (ClenEx, A) that clenbuterol (clen, b) the exercise (eg C) and control (Con; D) groups. Means of different letters (A and B) are significantly different. Changes in fat free mass (mission) over time in ClenEx (A), Člen (B), Ex (C) and Con (D). Means of different letters (AC), are quite different. I think these cards should illustrate clearly the effects of pre-Člen, despite what is known, its effects on animals are usually much larger than the population I. There is still no doubt, in my opinion, Člen will help you lose fat and gain muscle. So let us re-examine the first point I made: Člen + clen to produce approximately the same results for the first 2 weeks! This tells me that 2 weeks and 2 weeks of clen dosage is far from optimal, and if you want a quasi-anabolic effect of clen, it will take more than 2 weeks (6 weeks apparently). In addition, since clen alone is similar to clen + exercise for the first 2 weeks ... why you use 2on/2off protocol? Keep in mind that the responses of animals beta-agonist/antagonists slightly different from ours, but I am sure you have the idea that the greater the dose 2on/2off protocol. If I were using clen, I would use it for 6-12 weeks at a time when I expected to get the most out of it, but certainly the most dramatic consequences of the loss of fat seems to be in 1 -2 weeks. The reasons for the continued growth of the Mission for about 6 weeks, despite the lack of variation in% fat or fat is not easy to explain ... May clenbuterol It may be that the increase of the mission by another means nonreceptor mediation, which will be very good for us because the anabolic effects would also apply to individuals, despite the fact that animals often respond dramatically more beta-agonist/antagonists, as regards the properties of the receiver .. However, clenbuterol is liposoluble, between May and muscle tissue (12), which could indicate a possible mechanism of work. Perhaps to explain the significant increase in the mission of 13 kg for 8 weeks during the study? Of course, the muscle protein synthesis (MPS) should be part of it, since clen will increase MPS in the body (17) And he even suggested that the increased growth of the influence of clenbuterol in May to be specific muscles and that the drugs work in May was not yet understood in a manner which circumvents (!) the physiological mechanisms responsible for controlling muscle growth (13). This could mean that clenbuterol can help blast you past "to accede to your point, without going through the usual mechanisms by which the anabolism is experienced! It should be noted that both the composition and size of muscle fibers has been shown to increase with administration of clen (14). In any case, it is clear that the results you want to play to those received by clen + exercise for 6 weeks or more. This type of dramatic anabolic effect was not confirmed in human studies (8), the anabolic effects of clen animal (eg, horses and rodents) studies are clearly amazing. Now, when I told you how clen, I will tell you how to take and Clen has biphastic liquidation, which means it is technically reduced in the body in 2 stages. This is not particularly important, because a recent study showed that for most intents and purposes, clen concentrations in the body decline with ½ life (approximately), which is equivalent to 7-9,2 hours and again, with a maximum 35 hours (4) (5). If you are really concerned, then, clen technically biphastically drop 10 and then 36 hours. But really, in our little world, where we use ½ life for us, if we take our next dose, what the devil is going to take clen, then a dose of 10 hours, and then the dose of 36 hours? We will adhere to 7-9 and a half hours earlier for the determination of the purpose of life, and take our clen every 3.5-4.5 hours we're awake, stopping early to even be in a position to get to bed. Clen can, in some people cause insomnia (and, like all stimulants, can cause anxiety in some countries). Recently it has become popular to take massive doses of clen in the morning, and he had that day. There is nothing wrong with that, I think, but I do not want to go through this kind of roller coaster of the formation of fog and shake until it wore off. Clenbuterol cycle Based on its rate of elimination from the body, and how he would normally be effective for athletes, my recommendations are the same for men and women. You should take 20mcgs to increase, then repeat the dose later that day and again the same day (if you find you can live with the consequences). So you can start with 20mcgs, then repeat the dose 2 times the same day, if you can tolerate (side effects will determine this handshake, sweat, etc. And the classic stimulant sides). Then you can start increasing the doses gradually. Personally, I would not be my way to work more than 200mcg/day. 60-120mcg/day is the average dose. And save your blood pressure (or under) 140/90, and on clen, just to be sure. If you go to the lowest dose. Want to know the temperature of the body, a week before taking your clen, and then monitor it (again, as soon as you wake up) clen throughout your plan. When he returned to the level it was before you began taking the clen, you need to start taking Benadryl or Ketotifen, because the decrease in body temperature to return to baseline levels indicating thermogenic effect begins to decrease. Clenbuterol May also cause a decrease in testicular androgen receptor, and in the lung, heart and central nervous system beta-adrenergic receptors (6.) It is possible to make steroids less effective (if there is a decrease in receptor androgens, as elsewhere, it is very likely) if you are on clen, but certainly do clen less effective as time passes, and preserve its adoption. To counter this, you can take some ketotifen every 3 or 4 weeks that you continue to clen. This is a recipe for the fight against histimines to make you drowsy (take before bedtime). In principle, this method is to reduce beta-2 activity, and to restore the function of receptors (15). Another option, if you are worried about receptor versions, taking Benadryl, at around 50-100mgs/night before bed (every 3 weeks, this week). Benadryl is sold as an anti-histamine in the United States and / or sleep aid in other countries around the world. However, beta-receptors in the cell outside the membrane phospholipids. The stability of the membrane has a lot to do with the functioning of receptors. Methylation of phospholipid binding is stimulated by beta-agonists to receptors. Phospholipids METHYLATED have nothing to do with the body, but when the body recognizes as foreign, it breaks with the phospholipase A2. This change in the structure of the outer membrane, leading to desensitization of beta receptors. On the other hand, agents that inhibit the phospholipase A2 slow desensitization. Cationic ampiphylic drugs known for their ability to inhibit phospholipase A2. Benadryl (diphenhydramine) is a cationic drug ampiphylic. Ergo, Benadryl slows desensitization of Beta receptors (ie upgrade) to inhibit phospholipase A2, an enzyme that breaks methylated phospholipids, and these, in turn, leads to phospholipids membrane stable, and thus save the receptors functioning properly. (7). This will allow you to use clen much, and it will always have the same effect. Also, since Benadryl is an anti-histamine, and histamines have a direct effect on beta-blockers (not just Beta-2, but some of them), using anti-histamine will have a direct impact on reducing the stimulation of beta-(16) and consequently upregulating your beta-receptors. Ephedrine Since we are talking about beta-receptors and upregulation, here, let me address the assertion that you can use ephedrine (or the ECA stack), alternating with clen, so that receptors in the fall. I do not know where this rumor, but it is absolutely false. To dispel this myth, studies of ephedrine for a second. I remember when I said that using clenbuterol to stimulate beta-2 receptors, as a strike under the hammer? Well, ephedrine, a sledge-hammer, he hits the Beta 2 and everything around them. Because it is not selective because it stimulates other receptors to a large extent, too. Anyway, one of these receptors as ephedrine hits a beta-2 (as Člen yeah. ..). As can be seen in the graph below (ephedrine is a solid circles), it reduced the beta-2-AndrenergicReceptor (which we call, in laymen saying: "The beta-2) to 32% of control level after 24 hours. Read again: Ephedrine, the study reduced the beta-2 at 32% of control after 24 hours. (see solid circles in this column represent ephedrine) Of course, it is not perfect, it is not in a living organism, etc. .. but there is no doubt that ephedrine would downregulate beta-2 .... therefore, you can not use it for several weeks between your updated clen receptors. Clenbuterol side effects Also, keep in mind that clenbuterol has some side effects. It is not great for your heart, and May also cause problems (enlargement of ventricles, etc), but most studies showing clen to cause heart problems in animals, and even though the dosing is almost similar that people are (as in some studies, it ranged from what would be a double dose of great ...), it is important to remember that animals have more beta-2 receptors and they cause some event chains that humans receptor beta-2 May not. Clen causes cardiac hypertrophy and cardiac necrosis (cell death), to some extent, in some cases. Again, although many studies have shown a large, possibly irreversible, heart problems with mg dosing. We humans take clen in mcg doses. If we want to duplicate the "therapeutic" levels of clen seen in more conservative studies, we have a little more 1mcg/lb body twice a day. I suggest a little less than half this dose, however. Questions clen also vary. Some studies show reduced exercise (cardiovascular) performance with clen (9), while the show that clen can alleviate asthma caused by exercise (10)! Obviously this issue will have different effects on different people, and I suspect that many of its sporting character. Many bodybuilders claim that clen, it is difficult to cardio, but I can play a game of rugby on it. You need to see how it affects you, and adjust your dose personally. Finally, this brings me to the issue of cramps while clen. I do not receive them. My friends do not receive them. Most of us, athletes who use clen during the season and the season, and one of my friends even claims that this gives him more "wind" (cardiovascular endurance). To get enough water each day, and you should be good. If you're really worried, you can take a little more minerals and taurine, since clen depletes taurine (11), like most, if not all beta-agonists. I do nothing more than my vitamins and minerals. 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